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Keywords: a fever, a fervescence, pyrogens, pyrogenic reactions, mechanisms of rise in temperature, pathological physiology of a fever

PHYSIOPATHOLOGY of the FEVER.
Mechanisms of development, an etiology, stages, value of a fever

Key concepts

  1. the Fever (febris - to boil, burn, be hot) - sample pathological process of a fervescence in which basis neurohumoral mechanisms of rearrangement of a thermoregulation under influence of extreme irritants of a contagious and not contagious parentage lay. The basic pathophysiological exhibitings of a fever are - a fever (shiver), fever (fever), a diaphoresis (perspiration).
  2. Pyrogens (pyr - fever, fire, genesis - generating, effecting) - materials of the contagious and not contagious nature, capable to invoke a fever in an organism. High-molecular bonds which structure includes albuminous, carbohydrate and lipide components.
  3. the Termoregulation theory of a fever - the parentage of a fever is surveyed as rearrangement of neurohumoral mechanisms of a thermoregulation (mechanisms of a thermolysis and a heat production), accompanying by accumulation of heat in an organism.

Educational elements

I. A fever

  • a general characteristic
  • an etiology of a fever: contagious and not contagious fevers
  • classification of pyrogenic factors (initial and secondary pyrogens)
  • sources of formation endopirogenov
  • the chemical nature of pyrogens
  • mechanisms of action of pyrogens
  • dependence of development of a fever on properties of the pyrogenic factor

II. Stages of a fever

  • rise, standing, downstroke of a body temperature
  • a thermoregulation at different stages of a fever
  • phylums of feverish reactions

III. The cellular - metabolic mechanism of development of a fever

  • formation endopirogenov (leukocytic pyrogens, interlejkin I)
  • change of metabolic processes in thermogenic tissues
  • pirogenzavisimye metabolic mechanisms of formation of heat

IV. The reflex mechanism of development of a fever

  • the pathophysiological characteristic of termoregulation jerks
  • change of sensitivity of cold and thermal receptors
  • change of a temperature threshold of exaltation of the central thermoreceptors of a forward hypothalamus (preopticheskoj ranges)
  • value of peripheric receptors in rearrangement of a thermoregulation at a fever

V. The centrogenic mechanism of development of a fever

  • a pyrogenic boring of integrative center of a thermoregulation (a back hypothalamus)
  • direct and-or mediated (Prostaglandinums E1- tsAMF) action of pyrogens on not thermosensitive internuncial neurons of center of a thermoregulation
  • value of a functional state of thermosensitive regions of a forward hypothalamus (preopticheskoj ranges) in rearrangement of a thermoregulation at a fever

VI. The humoral mechanism of development of a fever

  • mediators and modulators of a fever
  • Prostaglandinums E1- adenilattsiklaza and-or fosfodiesteraza - tsAMF
  • catecholamins
  • mechanisms of a stimulation of feverish process
  • braking mechanisms of feverish process

VII. Change of physiological functions at a fever

  • the central nervous system (CNS)
  • endocrine system
  • system of a circulation
  • system of respiration
  • system of a blood
  • system of digestion
  • infringement of function of nephroses
  • physiological system of the immune answer
  • change of function of sialadens and states of a mucous oral cavity at a fever

VIII. A pathology of a metabolism at a fever

  • the basic exchange
  • an albuminous exchange
  • carbohydrate metabolism
  • a lipometabolism
  • water and elektrolitnyj an exchange

IX. A fever and a reactivity of an organism

  • dependence of development of a fever on a reactivity of an organism
  • a fever in phylogenesis
  • a fever in an ontogenesis
  • features of a fever at early age

X. Biological value of a fever

  • protective - adaptive reactions of an organism at a fever
  • pathological reactions of an organism at a fever
  • pathophysiological principles of antipyretic therapy
  • concept about a pyrotherapy

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Keywords: a fever, a fervescence, pyrogens, pyrogenic reactions, mechanisms of rise in temperature, pathological physiology of a fever
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